Publikationen

• Coomaraswamy J, Kilger E, Wölfing H, Schäfer S, Kaeser SA, Wegenast-Braun BM, Hefendehl JK, Wolburg H, Mazzella M, Ghiso J, Goedert M, Akiyama H, Garcia-Sierra F, Wolfer DP, Mathews PM, Jucker M (2010) Modeling Familial Danish Dementia in mice supports the concept of the amyloid hypothesis of Alzheimer´s disease. Proc Natl Acad Sci USA 107:7969-74 (Abstract)

• Eisele YS, Obermuller U, Heilbronner G, Baumann F, Kaeser SA, Wolburg H, Walker LC, Staufenbiel M, Heikenwalder M, Jucker M (2010) Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis. Science 330:980-2 (Abstract)

• Jucker M (2010) The benefits and limitations of animal models for translational research inneurodegenerative diseases. Nat Med 16:1210-4 (Abstract)

• Eisele YS, Bolmont T, Heikenwalder M, Langer F, Jacobson LH, Yan ZX, Roth K, Aguzzi A, Staufenbiel M, Walker LC, Jucker M (2009) Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation. Proc Natl Acad Scu USA, 106:12926-31 (Abstract)

• Grathwohl SA, Kalin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, Jucker M (2009) Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nat Neurosci 12:1361-3 (Abstract)

• Herzig MC, Eisele YS, Staufenbiel M, Jucker M (2009) E22Q-mutant Abeta peptide (AbetaDutch)increases vascular but reduces parenchymal Abeta deposition. The American Journal of Pathology 174:722-6 (Abstract)

• Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, Fraser G, Stalder AK, Beibel M, Staufenbiel M, Jucker M, Goedert M, Tolnay M (2009) Transmission and spreading of tauopathy in transgenic mouse brain. Nature Cell Biology 11:909-13 (Abstract)

• Wegenast-Braun BM, Fulgencio Maisch A, Eicke D, Radde R, Herzig MC, Staufenbiel M, Jucker M, Calhoun ME (2009) Independent effects of intra- and extracellular Abeta on learning-related gene expression. American Journal of Pathology 175:271-82 (Abstract)

• Jucker M, Heppner FL (2008) Cerebral and peripheral amyloid phagocytes - an old liaison with a new twist. Neuron 59:8-10 (Abstract)
  
  
• Bolmont T, Haiss F, Eicke D, Radde R, Mathis CA, Klunk WE, Kohsaka S, Jucker M, Calhoun ME (2008) Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance. Journal of Neuroscience 28:4283-92 (Abstract)
  
  
• Ermini FV, Grathwohl S, Radde R, Yamaguchi M, Staufenbiel M, Palmer TD, Jucker M (2008) Neurogenesis and alterations of neural stem cells in mouse models of cerebral amyloidosis. American Journal of Pathology 172:1520-8 (Abstract)

• Burbach GJ, Vlachos A, Ghebremedhin E, del Turco D, Coomaraswamy J, Staufenbiel M, Jucker M, Deller T (2007) Vessel ultrastructure in APP23 transgenic mice after passive anti-Aß immunotherapy and subsequent intracerebral hemorrhage. Neurobiology of Aging, 28:202-12 (Abstract)
  
  
• Kaeser S, Herzig M, Coomaraswamy J, Kilger E, Selenica ML, Winkler D, Staufenbiel M, Levy E, Grubb A, Jucker M (2007) Cystatin C modulates cerebral ß-amyloidosis, Nature Genetics, 39:1437-9 (Abstract)
  
  
• Bolmont T, Clavaguera F, Meyer-Luehmann M, Herzig M, Radde R, Staufenbiel M, Lewis J, Hutton M, Tolnay M, Jucker M (2007) Induction of tau pathology by intracerebral infusion of Amyloid-ß-containing brain extract and by Amyloid-ß-deposition in APP x tau transgenic mice, American Journal of Pathology, 171:2012-20 (Abstract)
  
  
• Eisele Y, Baumann M, Klebl B, Nordhammer C, Jucker M, Kilger E (2007) Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-ß-degrading enzyme neprilysin, Molecular Biology of the Cell, 18:3591-600 (Abstract)
  
  
• Herzig MC, Paganetti P, Staufenbiel M, Jucker M (2007) BACE1 and mutated presenilin-1 differently modulate Aß40 and Aß42 levels and cerebral amyloidosis in APPDutch transgenic mice. Neurodegenerative Dis, 4:127-35 (Abstract)

• Herzig MC, van Nostrand WE, Jucker M (2006) Mechanism of cerebral ß-amyloid angiopathy: murine and cellular models. Brain Pathology 16:40-54 (Abstract)
  
  
• Walker L, Le Vine III H, Mattson MP, Jucker M (2006) Inducible proteopathies. Trends in Neurosciences 29:438-43 (Abstract)

• Walker L, LeVine H, Jucker M (2006) Koch's postulates and transmissible proteopathies. Acta Neuropathol 112:1-4 (Abstract)
  
  
• Radde R, Bolmont T, Käser SA, Coomaraswamy J, Lindau D, Stoltze L, Calhoun ME, Jäggi F, Wolburg H, Gengler S, Haass C, Ghetti B, Czech C, Hölscher C, Mathews PM, Jucker M (2006) Ab42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO reports 7:940-6 (Abstract)
  
  
• Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret J, Paganetti P, Walsh DM, Mathews P, Ghiso J, Staufenbiel M, Walker L, Jucker M (2006) Exogenous induction of Ab-amyloidogenesis is governed by agent and host. Science 313:1781-4 (Abstract)

• Boncristiano S, Calhoun ME, Howard V, Bondolfi L, Kaeser SA, Wiederhold KH, Staufenbiel M, Jucker M (2005) Neocortical synaptic bouton number is maintained despite robust amyloid deposition in APP23 transgenic mice. Neurobiology of Aging 26: 607-13 (Abstract)
  
  
• Syková E, Voíek I, Antonova T, Mazel T, Meyer-Luehmann M, Jucker M, Hájek M, Ort M, Bure J (2005). Changes in extracellular space size and geometry in APP23 transgenic mice - a model of Alzheimer’s disease. Proc. Natl. Acad. Sci. USA 102: 479-84 (Abstract)
  
  
• Stalder AK, Ermini F, Bondolfi L, Krenger W, Burbach G, Deller T, Coomaraswamy J, Staufenbiel M, Landmann R, Jucker M (2005) Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice. Journal of Neuroscience 25:11125-32 (Abstract)

• Bondolfi L, Ermini F, Long JM, Ingram DK, Jucker M (2004). Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice. Neurobiology of Aging 25: 333-40  (Abstract)
  
• Phinney AL, Calhoun ME, Woods AG, Deller T, Jucker M (2004). Stereological analysis of the reorganization of the dentate gyrus following entorhinal cortex lesion in mice. European Journal of Neuroscience 19: 1731-40  (Abstract)
  
  
• Burbach GJ, Hellweg R, Haas CA, Del Turco D, Deicke U, Abramowski D, Jucker M, Staufenbiel M, Deller T (2004). Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice. Journal of Neuroscience 24: 2421-30  (Abstract)
  
• Mueggler T, Meyer-Luehmann M, Rausch M, Staufenbiel M, Jucker M, Rudin M (2004) Restricted diffusion in the brain of transgenic mice with cerebral amyloidosis. European Journal of Neuroscience 20: 811-7  (Abstract)
  
  
• Herzig MC, Winkler DT, Burgermeister P, Pfeifer M, Kohler E, Schmidt SD, Danner S, Abramowski D, Stürchler-Pierrat C, Bürki K, van Duinen SG, Maat-Schieman MLC, Staufenbiel M, Mathews PM, Jucker M (2004). Aß is targeted to the vasculature in a mouse model of Hereditary Cerebral Hemorrhage with Amyloidosis. Nature Neuroscience 7: 954-60 (Abstract)

• Meyer-Luehmann M, Stalder M, Herzig MC, Käser S, Kohler E, Pfeifer M, Boncristiano S, Mathews PM, Mercken M, Abramowski D, Staufenbiel M, Jucker M (2003) Extracellular amyloid formation and associated pathology in neural grafts. Nature Neuroscience 6:370-7 (Abstract)

• Pfeifer M, Boncristiano S, Bondolfi L, Stalder A, Deller T, Staufenbiel M, Mathews P, Jucker M (2002) Cerebral hemorrhage following anti-Aß-immunotherapy. Science 298:1379 (Abstract)

• Winkler D, Biedermann L, Tolnay N, Allegrini PR, Staufenbiel M, Wiessner C, Jucker M (2002) Thrombolysis induces cerebral hemorrhage in a mouse model of cerebral amyloid angiopathy. Annals of Neurology 51:790-3 (Abstract)

• Bondolfi L, Calhoun M, Ermini F, Kuhn HG, Wiederhold KH, Walker L, Staufenbiel M, Jucker M (2002) Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice. Journal of Neuroscience 22:515-22 (Abstract)
  
  
• Boncristiano S, Calhoun ME, Kelly PH, Pfeifer M, Bondolfi L, Stalder M, Phinney AL, Abramowski D, Sturchler-Pierrat C, Enz A, Sommer B, Staufenbiel M, Jucker M (2002) Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis. Journal of Neuroscience 22:3234-43 (Abstract)
  
  
• Winkler D, Bondolfi L, Herzig M, Jann L, Calhoun ME, Wiederhold KH, Tolnay M, Staufenbiel, Jucker M (2001) Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy. Journal of Neuroscience 21:1619-27 (Abstract)
  
  
• Phinney AL, Deller T, Stalder M, Calhoun ME, Frotscher M, Sommer B, Staufenbiel M, Jucker M (1999) Cerebral amyloid induces aberrant axonal sprouting and ectopic terminal formation in amyloid precursor protein transgenic mice. Journal of Neuroscience 19:8552-9 (Abstract)
  
• Calhoun ME, Burgermeister P, Phinney AL, Stalder M, Tolnay M, Wiederhold KH, Abramowski D, Stürchler-Pierrat C, Sommer B, Staufenbiel M, Jucker M (1999) Neuronal overexpression of mutant APP results in prominent deposition of cerebrovascular amyloid. Proc. Natl. Acad. Sci. USA 96:14088-93 (Abstract)
  
  
• Calhoun ME, Wiederhold KH, Abramovski D, Phinney AL, Probst A, Sturchler-Pierrat C, Staufenbiel M, Sommer B, Jucker M (1998) Neuron loss in APP transgenic mice. Nature 395:755-6 (Abstract)

• Jucker M, Walker LC, Martin L, Kitt C, Kleinman H, Ingram D, Price D, Wirak D, Bayney R, Ramabhadran T, Fracasso R, Hart J, Hauer P, Hsiau P, Pekar S, Scangos G, Trap B, Unterbeck A (1992) Age-Associated Inclusions in Normal and Transgenic Mouse Brain. Science 255:1443-5 (Abstract)

List of Publications Cellular Neurology